23 Feb 2018

Photo of the week: 2018 BMedSc(Hons) students


2018 CCS BMedSc(Hons) group with this year's BMedSc(Hons) coordinators, Prof Karin Jandeleit-Dahm (second from left) and Prof Merlin Thomas (on the right). Visit the BMedSc(Hons) webpage for more information about the course

What's On at CCS 26 Feb - 2 Mar 2018

Mitchell Moon presents Tue 27 Feb
PhD mid-candidature review
Central Clinical School (CCS) has regular seminar series and postgraduate presentations. Event notices are posted on the CCS Events calendar.
 
CCS staff and students can see details of both public and local events (including professional development courses, trade fairs and Graduate Research Student calendars) and deadlines, at the CCS intranet's Announcements page.

See CCS seminar index:  www.med.monash.edu.au/cecs/events/seminars.html

What's on at CCS 26 Feb - 02 Mar 2018

Recent CCS publications: 5 - 12 February 2018

Dr Devi Deliyanti and Professor Jennifer Wilkinson-Berka,
Department of Diabetes, have two publications listed this week,
on mechanisms to reduce retinal vascular damage
Recent publications for Central Clinical School affiliated authors in the following departments. Note, browse down this entry for complete publications list. Linked headings for each section are to the departments' home pages.
  • Respiratory Medicine (ResMed)
  •  Anaesthesia and Perioperative Medicine
  •  Australian Centre for Blood Diseases (ACBD)
  •  Diabetes
  •  Gastroenterology
  •  Immunology and Pathology
  •  Infectious Diseases
  •  Medicine
  •  Melbourne Sexual Health Centre (MSHC)
  •  Monash Alfred Psychiatry research centre (MAPrc) 
  •  National Trauma Research Institute
  •  Neuroscience
  •  Surgery and Centre for Obesity Research and Education (CORE)

Exploring the brave new world of the epigenome

Professor Sam El-Osta's (second from right, back row) research group
by Anne Crawford

When it comes to the epigenome, there is a fine line between clarity and confusion—walk that line and you will discover another fascinating level of transcription control.

So begins a review of the current state-of-play of studies into epigenetics in diabetic complications led by Professor Sam El-Osta from Monash University’s Department of Diabetes. The paper, which focusses particularly on the complication diabetic nephropathy (kidney disease), appeared on the cover of last month’s edition of ‘Diabetologia’.

Media mention: Short Chain Fatty Acids, Francine Marques and Paul Gill

Researchers PhD student Paul Gill (Monash University)
and Dr Francine Marques (Baker Institute). Image: The Age
The Age published a story on research performed at Baker Institute by Dr Francine Marques (Twitter handle @FZMarques) that has shown that products of fermentation of dietary fibres by the gut microbiota (short-chain fatty acids, SCFAs) protect mice from developing hypertension (the initial paper was published at the beginning of 2017). Francine is now hoping to translate these findings into humans and has begun to examine if there is a link between short-chain fatty acids and blood pressure in humans with hypertension.

 

As part of Paul Gill's PhD, he has been measuring SCFAs from Francine's patient samples. Paul has also been measuring SCFAs in many fermented foods and beverages. Some of the foods that he found to be high in SCFAs were vinegars, kombucha, pickled foods, kimchi and soft cheeses (which have been marketed to have 'health benefits', many of which are completely unsubstantiated).

Paul says, "We are now using this information to formulate a 'high SCFA diet', that we think could have therapeutic value in conditions such as hypertension, but also immune disease." And, watch this space, Paul is currently designing a dietary intervention study (hopefully launching by April-May) in order to investigate this - so we'll be calling out for recruits!


 
Age story link: https://www.theage.com.au/national/a-make-or-break-moment-for-what-may-be-a-new-miracle-molecule-20180216-p4z0ky.html

Participants sought: Are you interested in brain science and what happens after a head injury?

Volunteers wanted with NO history of
head injury for study.

 
Traumatic brain injury Are you interested in brain science and what happens after a head injury?

PhD student Hannah Coyle's project is investigating traumatic brain injury, and involves using a non-invasive type of brain stimulation to learn more about changes post concussion and during recovery.

We need volunteers who have NO history of head injury to act as a comparison group. Participation will involve visiting our research centre in Prahran for three research sessions over a 6 month period.

Sessions take approximately 3 hours each.You will be compensated for your time and travel costs. Together we will complete an interview, do some thinking tasks, take a recording of your brain waves and give you a short session of non-invasive brain stimulation.

If you think this sounds interesting and would like to know more please contact Ms Hannah Coyle on 9076 9823 or at hannah.coyle@monash.edu

16 Feb 2018

Photo of the week: Honours cohort

2017's CCS Honours students. We are welcoming a large cohort of Honours students this year (50!), on Thursday 22 February, and will publish a group photo to https://www.monash.edu/medicine/ccs/education/current-students/current-honours.

What's on at CCS 19-23 Feb 2018

Shara Ket presents Mon 19 Feb
PhD mid-candidature review
Central Clinical School (CCS) has regular seminar series and postgraduate presentations. Event notices are posted on the CCS Events calendar.
CCS staff and students can see details of both public and local events (including professional development courses, trade fairs and Graduate Research Student calendars) and deadlines, at the CCS intranet's Announcements page.

See CCS seminar index:  www.med.monash.edu.au/cecs/events/seminars.html

What's on at CCS 19-23 Feb 2018

Recent CCS publications: 23 - 30 January 2018

A/Prof Kate Hoy (left) with a colleague and research participant.
Kate is first author on a study using tACS and tDCS to  investigate
the pathophysiology of working memory impairment in schizophrenia.
Recent publications for Central Clinical School affiliated authors in the following departments. Note, browse down this entry for complete publications list. Linked headings for each section are to the departments' home pages.
  •  Allergy, Immunology and Respiratory              Medicine (AIRMed) 
  •  Australian Centre for Blood Diseases (ACBD)
  •  Diabetes
  •  Immunology and Pathology
  •  Infectious Diseases
  •  Medicine
  •  Melbourne Sexual Health Centre (MSHC)
  •  National Trauma Research Institute,
  •  Monash Alfred Psychiatry research centre (MAPrc) 
  •  Neuroscience
  •  Surgery

Putting mindfulness to the test

Theta connectivity averaged across
conditions. Image: Neil Bailey
by Anne Crawford

Mindfulness meditation with its images of people sitting cross-legged and closed-eyed was once thought of as being almost mystical, but scientific studies are revealing very tangible benefits to those practising it and observable changes in the brain.

The practice has been shown to be effective for preventing the relapse of depression and for other mental illnesses such as anxiety, for relieving stress and helping with chronic pain. People who use it show improved attention.

But the cause of these changes is unclear and under-researched. Now, a Monash Alfred Psychiatry Research Centre (MAPrc) study is set to look for the mechanism that leads to the practice’s positive effects.

9 Feb 2018

Videos of the week: Andrew Wei and David Curtis

A/Profs David Curtis and Andrew Wei both have feature stories published this week on their research which will receive funding for clinical trials. See more about David and Andrew, and about the forthcoming research studies:

What's on at CCS 12-16 Feb 2018

Kasha Singh is presenting
final PhD review 14/2/18
Central Clinical School (CCS) has regular seminar series and postgraduate presentations. Event notices are posted on the CCS Events calendar.
 
CCS staff and students can see details of both public and local events (including professional development courses, trade fairs and Graduate Research Student calendars) and deadlines, at the CCS intranet's Announcements page.

See CCS seminar index:  www.med.monash.edu.au/cecs/events/seminars.html

What's on at CCS 12-16 Feb 2018

Mon 12/02/2018 12:00 Neuroscience seminar series
Tue 13/02/2018 11:00 PhD Mid-Candidature review: Wing Yu Man
Wed 14/02/2018 10:30 PhD Final review: Kasha Singh
11:30 PhD Pre-Submission review: Alicia Chenoweth
Thur 15/02/2018 11:30 Cutting Edge Journal Club: Craig McKenzie


12:00 Alfred Grand Rounds: David Ruschena

Recent CCS publications: 9 - 22 Jan 2018

A/Prof Jane Muir and Dr Marina Iacovou evaluate a comparison
of yoga and FODMAP dietary intervention for managing IBS.
Image: 5 Yoga Poses for IBS 
Recent publications for Central Clinical School affiliated authors in the following departments. Note, browse down this entry for complete publications list. Linked headings for each section are to the departments' home pages.
  •  Allergy, Immunology and Respiratory Medicine (AIRMed) 
  •  Australian Centre for Blood Diseases (ACBD)
  •  Obesity Research and Education (CORE)
  •  Diabetes
  •  Gastroenterology
  •  Immunology and Pathology
  •  Infectious Diseases
  •  Medicine
  •  Melbourne Sexual Health Centre (MSHC)
  •  Monash Alfred Psychiatry research centre (MAPrc) 
  •  Neuroscience

Monash researchers to run world-first leukaemia “platform” trial

A/Prof Andrew Wei in clinic. A/Prof Wei researches AML.
Still from "Meet our research champion: Dr Andrew Wei"
by Anne Crawford

A national clinical trial program led by Monash University researchers testing drugs that may help patients with an aggressive form of leukaemia has been awarded a federal government grant of more than $1.5million.

The program, investigating treatments for Acute Myeloid Leukaemia (AML), is being funded by the Medical Research Future Fund’s (MRFF) Rare Cancers, Rare Diseases and Unmet Needs Clinical Trials Program.

Monash rare disease drug trial gets $1.5 million boost

A/Prof David Curtis, left, in clinic.
Still from Monash University at AMREP video
by Anne Crawford

Monash University researchers will start a national clinical trial into a new treatment for a life-threatening complication that follows bone marrow transplant, thanks to a $1.5
million federal government grant.

Associate Professor David Curtis was among four medical researchers from Monash University and The Alfred Hospital awarded more than $5.5million under the Medical Research Future Fund’s (MRFF) Rare Cancers, Rare Diseases and Unmet Needs Clinical Trials Program.

MAPrc study probes dark side of perimenopause

Suicide rates are alarmingly high among middle-aged women, and under-recognised and under-treated perimenopausal depression could be the culprit, says Professor Jayashri Kulkarni, director and founder of the Monash Alfred Psychiatry centre (MAPrc), in an interview posted on the MAPrc site.

Professor Kulkarni discusses early research she and her team have conducted into the hormone therapy Tibolone for addressing depression, which was “very encouraging”.

MAPrc are currently recruiting participants for a study into this.
Click here for more information about the research and to read The Medical Republic interview.


8 Feb 2018

2018 MIME Seed Fund meeting invitation

Monash Institute of Medical Engineering (MIME) is preparing to launch its annual seed fund. The 2018 MIME Seed Fund will be launched through a series of affinity meetings with our partner hospitals. Researchers are strongly encouraged to attend these meetings if they are interested in collaborating with clinicians as part of the 2018 MIME Seed Fund.

Click on the links below to RSVP to attend the meetings and check details of location etc.

Participants sought: How does your brain work during emotional processes?

Volunteers wanted for fMRI research study on emotion regulation. 
Image: Glass Brain
Investigating emotion regulation in healthy controls: An fMRI study

If you are female, aged between 20 and 50 years of age, right-handed and do not have a history of chronic low back pain, we would LOVE to hear from you! We are seeking volunteers to participate in a research study exploring brain structure and function during emotional processes.

2 Feb 2018

Video of the Week: Dr Steven Petratos

Still of Steven Petratos and his group from the video
Dr Steven Petratos, head of the Regenerative Neuroscience and Development Laboratory discusses his laboratory's recent discovery of a novel drug that could potentially help patients with Secondary Progressive MS, the stage that follows relapse and remission.


What's on at CCS 05-09 Feb 2018

Prof Patrick Kwan will be
the keynote speaker at
Thursday's Grand Rounds
Central Clinical School (CCS) has regular seminar series and postgraduate presentations. Event notices are posted on the CCS Events calendar.

CCS staff and students can see details of both public and local events (including professional development courses, trade fairs and Graduate Research Student calendars) and deadlines, at the CCS intranet's Announcements page.





What's on at CCS 05-09 Feb 2018

Wed 07/02/2018   ► 14:00   PhD Confirmation Milestone: Amy Searle
                              ► 14:30   PhD Confirmation Milestone: Anna Beale    
                               16:45   AMREP students Free Yoga
Thur 08/02/2018   ► 11:30   Cutting Edge Journal Club: Cassandra Castelino  
                              ► 12:00  The Alfred Grand Round: Sleep & Epilepsy
                              

Recent CCS publications: 1 - 9 January 2018

Shauna French and Justin Hamilton. Shauna is Justin's
PhD student and has two publications listed this week
on anti-thrombotic research.
Recent publications for Central Clinical School affiliated authors in the following departments. Note, browse down this entry for complete publications list. Linked headings for each section are to the departments' home pages.
  •  Allergy, Immunology and Respiratory Medicine (AIRMed)
  •  Anaesthesia and Perioperative Medicine
  •  Australian Centre for Blood Diseases (ACBD)
  •  Diabetes
  •  Gastroenterology
  •  Immunology and Pathology
  •  Infectious Diseases
  •  Medicine
  •  Melbourne Sexual Health Centre (MSHC)
  •  Monash Alfred Psychiatry research centre (MAPrc) 
  •  National Trauma Research Institute
  •  Neuroscience
  •  Surgery and Centre for Obesity Research and Education (CORE)

Recent CCS publications: 15 Dec 2017 - 1 Jan 2018

Prof Leon Bach, Department of Medicine
(Alfred) published a paper on insulin-like
growth factor binding proteins, implicated
in disorders including malignant, metabolic,
neurological and immune diseases
Recent publications for Central Clinical School affiliated authors in the following departments. Note, browse down this entry for complete publications list. Linked headings for each section are to the departments' home pages.



  • Allergy, Immunology and Respiratory Medicine (AIRMed)
  • Anaesthesia and Perioperative Medicine
  • Australian Centre for Blood Diseases (ACBD)
  • Centre for Obesity Research and Education (CORE)
  • Diabetes
  • Gastroenterology
  • Infectious Diseases
  • Immunology
  • MAPrc
  • Medicine
  • Melbourne Sexual Health Clinic (MSHC)
  • Neuroscience
  • Surgery

  • Funding boost for research on rare cancers and diseases

    L-R: A/Prof Andrew Wei, A/Prof David Curtis, A/Prof Erica Wood and Prof David Pilcher
    Congratulations to the medical researchers from The Alfred and Monash University who have scooped more than $5.5million in funding to tackle rare cancers and diseases!

    The four major research projects were among 19 Australia-wide to receive federal government backing under the Medical Research Future Fund’s Rare Cancers, Rare Diseases and Unmet Needs Clinical Trials Program.

    Holding hands a way to ease pain, study finds

    Holding hands with someone you love helps reduce perception
    of pain. Photo: Thinkstock
    by Anne Crawford

    Holding hands – an intimate moment, a gesture of reassurance or a show of friendship and connection.

    Now a Monash University study demonstrates that this simple gesture can have an analgesic effect on stress and pain, supporting the role of social connections in managing pain in clinical settings.

    29 Jan 2018

    Molecule may help halt MS progression, says Monash scientist

    Dr Steven Petratos 
    by Anne Crawford

    Monash University researchers are set to conduct a large study into a drug that may thwart the progression of Multiple Sclerosis (MS).

    The preclinical study, led by Dr Steven Petratos from the Department of Neuroscience, was given the go-ahead after MS Research Australia announced a $70,000 grant to support it. If successful, clinical trials would follow.

    International infection protocol challenged

    Professor Paul Myles
    by Anne Crawford

    The World Health Organization (WHO)’s recommended guidelines on surgical wound infection, one of the most common serious post-operative complications, has been questioned by Monash University researcher and Alfred Health clinician Professor Paul Myles.

    Patients with surgical site infections (SSI) are twice as likely to need admission to intensive care as other post-operative patients and are twice as likely to die. Surgical site infections are estimated to require an extra two million bed days a year and are believed to add a one billion-dollar cost to health care providers in Australia.

    Media mentions: Sexually transmitted disease study

    Prof Christopher Fairley
    Melbourne Sexual Health Centre research reporting that gonorrhoea and syphilis cases are on the rise again in Melbourne have appeared in several media outlets over the summer break.

    The centre's study described trends in sexually transmitted infection over nearly a century of data from 1918 to 2016.

    Researchers speculated that casual sex through online dating, and reduced fear of HIV, could be factors behind the recent trend.
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